One tool that may be of use to community pharmacists is the Methotrexate Adherence Questionnaire (see Methotrexate adherence questions). It helps to identify patients who may be non-adherent to treatment, and to provide some indication of the possible reasons for this, such as side effects that may be particularly problematic for the patient (27). Methotrexate reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). I’ve done a lot of reading on methotrexate and ectopic pregnancy. I feel I understand both sides of the argument. My problem is not knowing where I stand. I am a pharmacist in a hospital and we do occasionally treat e… Guidance for Pharmacists on Safe Supply of Oral Methotrexate 1. Introduction Methotrexate is a potent immunosuppressant used in the treatment of active rheumatoid arthritis in Practice guidelines for pharmacists The pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs Carolyn Bornstein , BScPhm, ACPR, CGP, FCSHP, RPh, Marie Craig , BScPhm, RPh, and Diane Tin , BScPhm, CDE, CGP, RPh Judy Sommers Hanson, PharmD, FAPhA, chats with Pharmacy Times about the important role that pharmacists can play in educating the public on B1 and methotrexate use. of methotrexate. All pharmacists and other staff must be aware of the need for extra vigilance around the supply and use of methotrexate, in particular the importance of weekly dosing and of awareness of symptoms of overdosage or toxicity. The methotrexate policy and procedure(s) should be reviewed and updated regularly in accordance with best professional practice, annually at a minimum and. Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. A 72-year-old female with a history of rheumatoid arthritis and multiple hospital admissions for pulmonary problems was started on oral methotrexate 10 mg once weekly.